Cutaneous squamous cell carcinoma (CSCC) is the second most deadly form of skin cancer1-4

It is estimated that approximately 7,000 people in the United States die every year from CSCC1,5,6,*

Many patients with advanced CSCC have a poor prognosis.7 While most early-stage CSCC is curable with complete surgical excision and radiation, patients with advanced CSCC face poor outcomes.7-10

  • CSCC accounts for the majority of nonmelanoma skin cancer deaths1
  • CSCC incidence is expected to increase 2% to 4% each year11
  • Patients with CSCC have reported concerns about the spread of disease and the effects of surgeries that may be disfiguring12
  • Mortality above 70% has been reported for patients with regional or distant metastasis7,11,13
  • * Estimated annual mortality rate of 7,000 was calculated using estimated annual incidence of 700,000—as of 2012—from Rogers et al, 2015, and multiplying it by estimated annual mortality rate of 1% from Clayman et al, 2005.5,6

Historically, patients have lacked FDA-approved treatment options14,15

Evidence regarding systemic treatment for advanced CSCC has been limited.14-16

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  1. Califano JA et al. In: Amin MB et al, eds. AJCC Cancer Staging Manual. 8th ed. Springer; 2017:171-181.
  2. Karia PS et al. J Am Acad Dermatol. 2013;68(6):957-966.
  3. Cancer stat facts: melanoma of the skin. Surveillance, Epidemiology, and End Results Program website. https://seer.cancer.gov/statfacts/html/melan.html. Accessed April 8, 2019.
  4. Watson M et al. MMWR Morb Mortal Wkly Rep. 2015;64(47):1312-1314.
  5. Rogers HW et al. JAMA Dermatol. 2015;151(10):1081-1086.
  6. Clayman GL et al. J Clin Oncol. 2005;23(4):759-765.
  7. Brunner M et al. Head Neck. 2013;35(1):72-75.
  8. Skin cancer treatment (PDQ®). National Cancer Institute website. https://www.cancer.gov/types/skin/hp/skin-treatment-pdq. Updated April 26, 2018. Accessed April 8, 2019.
  9. Haisma MS et al. J Am Acad Dermatol. 2016;75(4):722-730.
  10. Mullen JT et al. Ann Surg Oncol. 2006;13(7):902-909.
  11. Burton KA et al [published online June 29, 2016]. Am J Clin Dermatol. 2016;17(5):491-508. doi:10.1007/s40257-016-0207-3
  12. Rhee JS et al [published online for public access]. Arch Facial Plast Surg. 2006;8(5):314-318. doi:10.1001/archfaci.8.5.314
  13. Oddone N et al. Cancer. 2009;115(9):1883-1891.
  14. Ribero S et al. Curr Opin Oncol. 2017;29(2):129-135.
  15. Stratigos A et al. Eur J Cancer. 2015;51(14):1989-2007.
  16. Alam M et al. J Am Acad Dermatol. 2018;78(3):560-578.